| First Author | Xu Z | Year | 2011 |
| Journal | PLoS One | Volume | 6 |
| Issue | 1 | Pages | e14514 |
| PubMed ID | 21267069 | Mgi Jnum | J:251995 |
| Mgi Id | MGI:6107291 | Doi | 10.1371/journal.pone.0014514 |
| Citation | Xu Z, et al. (2011) Evidence for OTUD-6B participation in B lymphocytes cell cycle after cytokine stimulation. PLoS One 6(1):e14514 |
| abstractText | Deubiquitinating enzymes (DUBs) are important regulators of cell proliferation. Here we identified a functional deubiquitinating enzyme, ovarian tumor domain-containing 6B (OTUD-6B). Mutation of the conserved Cys residue abolished its deubiquitinating activity in vitro. Otud-6b expression was induced with cytokine stimulation in both mouse Ba/F3 cells and primary B lymphocytes followed a rapid decrease. This rapid decrease was partially facilitated by tristetraprolin (TTP) destabilization of Otud-6b mRNA through AU-rich motifs. Enforced expression of OTUD-6B in Ba/F3 cells could block cell proliferation by arresting cells in G1 phase. In addition, cyclin D2 level was down-regulated when OTUD-6B WT was overexpressed. Therefore, down-regulation of Otud-6b expression after prolonged cytokine stimulation may be required for cell proliferation in B lymphocytes. |
