| First Author | Joyner AL | Year | 1985 |
| Journal | Cell | Volume | 43 |
| Issue | 1 | Pages | 29-37 |
| PubMed ID | 2416459 | Mgi Jnum | J:8126 |
| Mgi Id | MGI:56595 | Doi | 10.1016/0092-8674(85)90009-1 |
| Citation | Joyner AL, et al. (1985) Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene. Cell 43(1):29-37 |
| abstractText | Regions of the mouse and human genomes with strong homology to the Drosophila engrailed gene have been identified by Southern blot analysis. One mouse engrailed-like region, Mo-en.1, has been cloned and partially sequenced; homology with the engrailed gene is localized to a 180 bp engrailed-like homeo box and 63 nucleotides immediately 3' to it. The protein sequence this region can encode includes 81 amino acids, of which 60 (75%) are identical with those of the putative translation product of the corresponding engrailed sequence. These data suggest that Mo-en.1 represents a mouse homolog of a gene of the Drosophila engrailed gene complex. Mo-en.1 has been mapped to chromosome 1, indicating it is not linked to other homeo box sequences that have been mapped in the mouse genome. Analysis of poly(A)+ RNA extracted from teratocarcinoma cells and whole mouse embryos demonstrates that the conserved homeo box region of Mo-en.1 is expressed differentially during mouse embryogenesis. |
