| First Author | Tang ZL | Year | 1994 |
| Journal | Gene | Volume | 147 |
| Issue | 2 | Pages | 299-300 |
| PubMed ID | 7926819 | Mgi Jnum | J:20873 |
| Mgi Id | MGI:68940 | Doi | 10.1016/0378-1119(94)90087-6 |
| Citation | Tang ZL, et al. (1994) The primary sequence of murine caveolin reveals a conserved consensus site for phosphorylation by protein kinase C. Gene 147(2):299-300 |
| abstractText | We report here the cloning of the murine cDNA encoding caveolin, a known v-Src substrate and caveolar marker protein. Interestingly, analysis of the murine cDNA and comparison with caveolin from other species reveals a previously unrecognized consensus site for protein kinase C (PKC) phosphorylation. This finding could have important implications as (i) both the morphology and function of caveolae are dramatically affected by PKC activators; and (ii) PKC alpha is concentrated in isolated caveolin-rich membrane domains. In addition, this first step should facilitate the use of the mouse as a genetic system for elucidating the role of caveolin in caveolar functioning. |
