| First Author | Tachiiri A | Year | 2003 |
| Journal | Genes Immun | Volume | 4 |
| Issue | 2 | Pages | 153-9 |
| PubMed ID | 12618864 | Mgi Jnum | J:82820 |
| Mgi Id | MGI:2655788 | Doi | 10.1038/sj.gene.6363934 |
| Citation | Tachiiri A, et al. (2003) Genomic structure and inducible expression of the IL-22 receptor alpha chain in mice. Genes Immun 4(2):153-9 |
| abstractText | IL-22 is a newly identified member of the interferon/IL-10 family. In humans, IL-22 signals through a heteroduplex receptor consisting of IL-22R and CRF2-4/IL-10Rbeta. To investigate the physiological function of IL-22 and IL-22R, we isolated a cDNA encoding the mouse IL-22R, which has been a missing component of the functional receptor complex for mouse IL-22. Subsequently, we identified the genomic sequence of the mouse IL-22R gene by a database search. The gene consists of about 24 kb and is split into seven exons. Interestingly, intron 2 begins with a GC dinucleotide instead of the consensus GT, although otherwise the overall structure of the mouse IL-22R gene is strikingly similar to its human counterpart. The gene was mapped to mouse chromosome 4 in the region syntenic to the human IL-22R gene locus. In normal mice, IL-22R mRNA is detected at very low levels in restricted organs such as the kidney, liver, and lung. However, upon lipopolysaccharide stimulation, IL-22R mRNA expression is highly upregulated in the liver, in contrast to CRF2-4, which is expressed constitutively in a variety of tissues. Thus, the expression of the functional IL-22 receptor in the liver is regulated at the gene transcription level.Genes and Immunity (2003) 4, 153-159. doi:10.1038/sj.gene.6363934 |
