| First Author | Gatto D | Year | 2009 |
| Journal | Immunity | Volume | 31 |
| Issue | 2 | Pages | 259-69 |
| PubMed ID | 19615922 | Mgi Jnum | J:151883 |
| Mgi Id | MGI:4355479 | Doi | 10.1016/j.immuni.2009.06.016 |
| Citation | Gatto D, et al. (2009) Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses. Immunity 31(2):259-69 |
| abstractText | Humoral immunity depends on both rapid and long-term antibody production against invading pathogens. This is achieved by the generation of spatially distinct extrafollicular plasmablast and follicular germinal center (GC) B cell populations, but the signals that guide responding B cells to these alternative compartments have not been fully elucidated. Here, we show that expression of the orphan G protein-coupled receptor Epstein-Barr virus-induced gene 2 (EBI2, also known as GPR183) by activated B cells was essential for their movement to extrafollicular sites and induction of early plasmablast responses. Conversely, downregulation of EBI2 enabled B cells to access the center of follicles and promoted efficient GC formation. EBI2 therefore provides a previously uncharacterized dimension to B cell migration that is crucial for coordinating rapid versus long-term antibody responses. |
