| First Author | McNicholas J | Year | 1982 |
| Journal | Science | Volume | 218 |
| Issue | 4578 | Pages | 1229-32 |
| PubMed ID | 6815800 | Mgi Jnum | J:20091 |
| Mgi Id | MGI:68204 | Doi | 10.1126/science.6815800 |
| Citation | McNicholas J, et al. (1982) DNA sequence of the gene encoding the E alpha Ia polypeptide of the BALB/c mouse. Science 218(4578):1229-32 |
| abstractText | A 3.4-kilobase DNA fragment containing the gene coding for the E alpha chain of an Ia (I region-associated) antigen from the BALB/c mouse has been sequenced. It contains at least three exons, which correlate with the major structural domains of the E alpha chain-the two external domains alpha 1 and alpha 2, and the transmembrane-cytoplasmic domain. The coding sequence of the mouse E alpha gene shows striking homology to its counterpart at the DNA and protein levels. The translated alpha 2 exon demonstrates significant similarity to beta 2-microglobulin, to immunoglobulin constant region domains, and to certain domains of transplantation antigens. These observations and those of others suggest that the Ia antigen, transplantation antigen, and immunoglobulin gene families share a common ancestor. |
