| First Author | Mellor AL | Year | 1984 |
| Journal | Cell | Volume | 36 |
| Issue | 1 | Pages | 139-44 |
| PubMed ID | 6420070 | Mgi Jnum | J:7290 |
| Mgi Id | MGI:55761 | Doi | 10.1016/0092-8674(84)90082-5 |
| Citation | Mellor AL, et al. (1984) A nonpolymorphic class I gene in the murine major histocompatibility complex. Cell 36(1):139-44 |
| abstractText | DNA sequence analysis of a class I gene (Q10), which maps to the Qa2,3 locus in the C57BL/10 (H-2b haplotype) mouse, reveals that it is almost identical to a cDNA clone (pH16) isolated from a SWR/J (H-2q haplotype) mouse liver cDNA library. Exon 5, in particular, has an unusual structure such that a polypeptide product is unlikely to be anchored in the cell membrane. Our findings suggest that the two sequences are derived from allelic class I genes, which are nonpolymorphic, in contrast to H-2K allelic sequences from the same mice, and they may encode liver-specific polypeptides of unknown function. Our previous studies indicate that the Q10 gene is a potential donor gene for the generation of mutations at the H-2K locus by inter-gene transfer of genetic information. Thus the lack of polymorphism in class I genes at the Q10 locus implies either that they are not recipients for such exchanges or that selective pressure prevents the accumulation of mutations in genes at this locus. |
