| First Author | Maller Schulman BR | Year | 2008 |
| Journal | Cell Cycle | Volume | 7 |
| Issue | 24 | Pages | 3935-42 |
| PubMed ID | 19098426 | Mgi Jnum | J:152121 |
| Mgi Id | MGI:4356244 | Doi | 10.4161/cc.7.24.7397 |
| Citation | Maller Schulman BR, et al. (2008) The let-7 microRNA target gene, Mlin41/Trim71 is required for mouse embryonic survival and neural tube closure. Cell Cycle 7(24):3935-42 |
| abstractText | In the nematode Caenorhabditis elegans, the let-7 microRNA (miRNA) controls the timing of key developmental events and terminal differentiation in part by directly regulating lin-41. C. elegans lin-41 mutants display precocious cell cycle exit and terminal differentiation of epidermal skin cells. lin-41 orthologues are found in more complex organisms including both mice and humans, but their roles are not known. We generated Mlin41 mouse mutants to ascertain a functional role for Mlin41. Strong loss of function Mlin41 gene-trap mutants demonstrated a striking neural tube closure defect during development, and embryonic lethality. Like C. elegans lin-41, Mlin41 also appears to be regulated by the let-7 and mir-125 miRNAs. Since Mlin41 is required for neural tube closure and survival it points to human lin-41 (HLIN41/TRIM71) as a potential human development and disease gene. |
