| First Author | Bartsch S | Year | 1997 |
| Journal | Brain Res | Volume | 762 |
| Issue | 1-2 | Pages | 231-4 |
| PubMed ID | 9262180 | Mgi Jnum | J:41802 |
| Mgi Id | MGI:894500 | Doi | 10.1016/s0006-8993(97)00484-8 |
| Citation | Bartsch S, et al. (1997) Increased number of unmyelinated axons in optic nerves of adult mice deficient in the myelin-associated glycoprotein (MAG). Brain Res 762(1-2):231-4 |
| abstractText | We have recently demonstrated that the formation of myelin sheaths in the optic nerve of young postnatal mice deficient in the myelin-associated glycoprotein (MAG) is retarded when compared to age-matched wild-type mice. In the present study, we analyzed whether impaired myelination of retinal ganglion cell axons is detectable in adult MAG mutants. In optic nerves of 2- and 9-month-old MAG-deficient mice, we observed a significantly increased number of unmyelinated axons compared to age-matched wild-type mice. At both ages, unmyelinated axons in optic nerves of MAG mutants were of small caliber. The number of unmyelinated axons decreased significantly in 9-month-old MAG mutants when compared to 2-month-old MAG mutants, indicative of a slow and long-lasting myelination of axons in the mutant. Our observations support the view that MAG is involved in the initiation of myelination in the CNS. |
