| First Author | Liu BP | Year | 2002 |
| Journal | Science | Volume | 297 |
| Issue | 5584 | Pages | 1190-3 |
| PubMed ID | 12089450 | Mgi Jnum | J:230364 |
| Mgi Id | MGI:5758817 | Doi | 10.1126/science.1073031 |
| Citation | Liu BP, et al. (2002) Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science 297(5584):1190-3 |
| abstractText | Axonal regeneration in the adult central nervous system (CNS) is limited by two proteins in myelin, Nogo and myelin-associated glycoprotein (MAG). The receptor for Nogo (NgR) has been identified as an axonal glycosyl-phosphatidyl-inositol (GPI)-anchored protein, whereas the MAG receptor has remained elusive. Here, we show that MAG binds directly, with high affinity, to NgR. Cleavage of GPI-linked proteins from axons protects growth cones from MAG-induced collapse, and dominant-negative NgR eliminates MAG inhibition of neurite outgrowth. MAG-resistant embryonic neurons are rendered MAG-sensitive by expression of NgR. MAG and Nogo-66 activate NgR independently and serve as redundant NgR ligands that may limit axonal regeneration after CNS injury. |
