| First Author | Hoffer MJ | Year | 1993 |
| Journal | Biochem Biophys Res Commun | Volume | 191 |
| Issue | 3 | Pages | 880-6 |
| PubMed ID | 8466528 | Mgi Jnum | J:4321 |
| Mgi Id | MGI:52817 | Doi | 10.1006/bbrc.1993.1299 |
| Citation | Hoffer MJ, et al. (1993) The mouse low density lipoprotein receptor gene: cDNA sequence and exon-intron structure. Biochem Biophys Res Commun 191(3):880-6 |
| abstractText | The low density lipoprotein (LDL) receptor plays a central role in the cholesterol metabolism. The cDNA sequence of the mouse low density lipoprotein receptor (Ldlr) gene has been determined and shows 76% homology with the human gene. The exon-intron structure has been determined for the 129/J mouse strain. The gene is composed of 18 exons and spans a region of 28 kb. In addition, the promoter regions of the mouse and human genes are homologous. Northern blot analysis revealed an mRNA of approximately 5 kb. The cloning of the Ldlr gene will enhance the usefulness of the mouse for the study of cholesterol metabolism and, in particular, for carrying out gene targeting experiments. |
