| First Author | Arcangeli ML | Year | 2011 |
| Journal | Blood | Volume | 118 |
| Issue | 17 | Pages | 4609-19 |
| PubMed ID | 21868569 | Mgi Jnum | J:178387 |
| Mgi Id | MGI:5298286 | Doi | 10.1182/blood-2010-12-323972 |
| Citation | Arcangeli ML, et al. (2011) JAM-B regulates maintenance of hematopoietic stem cells in the bone marrow. Blood 118(17):4609-19 |
| abstractText | In adult mammals, hematopoietic stem cells (HSCs) reside in the bone marrow (BM) and are maintained in a quiescent and undifferentiated state through adhesive interactions with specialized microenvironmental niches. Although junctional adhesion molecule-C (JAM-C) is expressed by HSCs, its function in adult hematopoiesis remains elusive. Here, we show that HSCs adhere to JAM-B expressed by BM stromal cells in a JAM-C dependent manner. The interaction regulates the interplay between HSCs and BM stromal cells as illustrated by the decreased pool of quiescent HSCs observed in jam-b deficient mice. We further show that this is probably because of alterations of BM stromal compartments and changes in SDF-1alpha BM content in jam-b(-/-) mice, suggesting that JAM-B is an active player in the maintenance of the BM stromal microenvironment. |
