| First Author | Rall T | Year | 1987 |
| Journal | FEBS Lett | Volume | 224 |
| Issue | 2 | Pages | 365-71 |
| PubMed ID | 2826231 | Mgi Jnum | J:45409 |
| Mgi Id | MGI:1195394 | Doi | 10.1016/0014-5793(87)80486-6 |
| Citation | Rall T, et al. (1987) Identification of the lesion in the stimulatory GTP-binding protein of the uncoupled S49 lymphoma. FEBS Lett 224(2):365-71 |
| abstractText | The stimulatory GTP-binding protein (Gs) of the uncoupled mutant of S49 lymphoma cells is deficient in its ability to transduce hormonal signals from ligand-bound beta-adrenergic receptors to the catalytic component of adenylate cyclase. In order to define the genetic defect in the Gs of uncoupled S49 cells, a complementary DNA clone encoding the alpha-subunit of Gs was analyzed and the deduced primary structure of the defective subunit compared to that of the wild-type subunit. A single nucleotide transversion was found that coded for a proline rather than an arginine at residue 389. The results indicate a domain of the alpha-subunit of Gs that specifically interacts with hormone receptors. |
