| First Author | Glinka A | Year | 1998 |
| Journal | Nature | Volume | 391 |
| Issue | 6665 | Pages | 357-62 |
| PubMed ID | 9450748 | Mgi Jnum | J:51745 |
| Mgi Id | MGI:1326807 | Doi | 10.1038/34848 |
| Citation | Glinka A, et al. (1998) Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature 391(6665):357-62 |
| abstractText | The Spemann organizer in amphibian embryos is a tissue with potent head- inducing activity, the molecular nature of which is unresolved. Here we describe dickkopf-1 (dkk-1), which encodes Dkk-1, a secreted inducer of Spemann's organizer in Xenopus and a member of a new protein family. Injections of mRNA and antibody indicate that dkk-1 is sufficient and necessary to cause head induction. dkk-1 s a potent antagonist of Wnt signalling, suggesting that dkk genes encode a family of secreted Wnt inhibitors. |
