| First Author | Rojo S | Year | 1997 |
| Journal | J Immunol | Volume | 158 |
| Issue | 1 | Pages | 9-12 |
| PubMed ID | 8977169 | Mgi Jnum | J:314847 |
| Mgi Id | MGI:6828674 | Doi | 10.4049/jimmunol.158.1.9 |
| Citation | Rojo S, et al. (1997) Type I transmembrane receptor with inhibitory function in mouse mast cells and NK cells. J Immunol 158(1):9-12 |
| abstractText | The MHC class I-specific inhibitory receptors on human and mouse NK cells have surprisingly different structures. The mouse receptors (Ly-49) are type II transmembrane glycoproteins of the C-type lectin family, whereas the human receptors (killer cell inhibitory receptors (KIR)) belong to the Ig superfamily. This difference prompted a search for Ig-like inhibitory receptors in mice. Here we show that gp49, a mouse mast cell protein of unknown function but with sequence similarity to KIR, is expressed in NK cells. The gp49 cytoplasmic tail, containing a sequence related to an inhibitory motif shared by KIR and Ly-49, delivered a strong inhibitory signal in both human and mouse NK cells when substituted for a KIR cytoplasmic tail. These data show that Ig-like receptors with inhibitory properties exist in both species and that mouse mast and NK cells may recognize common inhibitory ligands. |
