| First Author | Silvestre JS | Year | 2005 |
| Journal | Nat Med | Volume | 11 |
| Issue | 5 | Pages | 499-506 |
| PubMed ID | 15834428 | Mgi Jnum | J:98314 |
| Mgi Id | MGI:3577828 | Doi | 10.1038/nm1233 |
| Citation | Silvestre JS, et al. (2005) Lactadherin promotes VEGF-dependent neovascularization. Nat Med 11(6):499-506 |
| abstractText | Vascular endothelial growth factor (VEGF)-induced blood vessel growth is involved in both physiological and pathological angiogenesis and requires integrin-mediated signaling. We now show that an integrin-binding protein initially described in milk-fat globule, MFG-E8 (also known as lactadherin), is expressed in and around blood vessels and has a crucial role in VEGF-dependent neovascularization in the adult mouse. Using neutralizing antibodies and lactadherin-deficient animals, we show that lactadherin interacts with alphavbeta3 and alphavbeta5 integrins and alters both VEGF-dependent Akt phosphorylation and neovascularization. In the absence of VEGF, lactadherin administration induced alphavbeta3- and alphavbeta5-dependent Akt phosphorylation in endothelial cells in vitro and strongly improved postischemic neovascularization in vivo. These results show a crucial role for lactadherin in VEGF-dependent neovascularization and identify lactadherin as an important target for the modulation of neovascularization. |
