| First Author | Ryder K | Year | 1989 |
| Journal | Proc Natl Acad Sci U S A | Volume | 86 |
| Issue | 5 | Pages | 1500-3 |
| PubMed ID | 2493644 | Mgi Jnum | J:9650 |
| Mgi Id | MGI:58107 | Doi | 10.1073/pnas.86.5.1500 |
| Citation | Ryder K, et al. (1989) jun-D: a third member of the jun gene family. Proc Natl Acad Sci U S A 86(5):1500-3 |
| abstractText | The protooncogene c-jun encodes a component of the transcription factor AP-1. Both murine c-jun and a related gene (jun-B) are rapidly activated in BALB/c3T3 cells by serum growth factors. We report here the cloning and analysis of a cDNA encoding a third member of the murine jun family, jun-D. The amino acid sequence encoded by jun-D has two extensive regions of homology with the other Jun proteins. One homology region includes the DNA-binding domain and sequences required for dimer formation and interaction with the Fos oncoprotein; the other includes the acidic sequence thought to be involved in gene activation. All three jun mRNAs are present in a variety of murine tissues and cell lines. In resting 3T3 cells, jun-D is expressed at a higher level compared to c-jun and jun-B, and its transcription is stimulated only slightly by serum growth factors. Thus, jun-D appears to be regulated differently than c-jun and jun-B. |
