| First Author | Ma RZ | Year | 2002 |
| Journal | Science | Volume | 297 |
| Issue | 5581 | Pages | 620-3 |
| PubMed ID | 12142541 | Mgi Jnum | J:77938 |
| Mgi Id | MGI:2182944 | Doi | 10.1126/science.1072810 |
| Citation | Ma RZ, et al. (2002) Identification of Bphs, an autoimmune disease locus, as histamine receptor H1. Science 297(5581):620-3 |
| abstractText | Bphs controls Bordetella pertussis toxin (PTX)-induced vasoactive amine sensitization elicited by histamine (VAASH) and has an established role in autoimmunity. We report that congenic mapping links Bphs to the histamine H1 receptor gene (Hrh1/H1R) and that H1R differs at three amino acid residues in VAASH-susceptible and -resistant mice. Hrh1-/- mice are protected from VAASH, which can be restored by genetic complementation with a susceptible Bphs/Hrh1 allele, and experimental allergic encephalomyelitis and autoimmune orchitis due to immune deviation. Thus, natural alleles of Hrh1 control both the autoimmune T cell and vascular responses regulated by histamine after PTX sensitization. |
