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Publication : Cloning and analysis of the murine Foxi2 transcription factor.

First Author  Wijchers PJ Year  2005
Journal  Biochim Biophys Acta Volume  1731
Issue  2 Pages  133-8
PubMed ID  16289364 Mgi Jnum  J:104058
Mgi Id  MGI:3611095 Doi  10.1016/j.bbaexp.2005.09.003
Citation  Wijchers PJ, et al. (2005) Cloning and analysis of the murine Foxi2 transcription factor. Biochim Biophys Acta 1731(2):133-8
abstractText  Forkhead transcription factors comprise a large family of key regulators of embryonic development. Here, we describe the cloning and analysis of the murine Foxi2 gene, coding for a putative 311 amino acid protein resembling Foxi subfamily members in mice and other species. Expression analysis during the final stages of embryonic development revealed that Foxi2 expression is mainly confined to subsets of cells in epithelial structures and particular ducts, in addition to the developing forebrain and neural retina. Since FoxI factors are thought to be implicated in the regulation of cell fate, the highly restricted expression pattern of Foxi2 suggestive of a possible role in controlling cellular identity.
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