Other
15 Authors
- Hart TC,
- Ding H,
- O'Rourke M,
- Nagy A,
- Kim I,
- Wu X,
- Tam PP,
- Boström H,
- Tsoi B,
- Koh GY,
- Soriano P,
- Wong N,
- Field LL,
- Marazita ML,
- Betsholtz C
| First Author | Ding H | Year | 2004 |
| Journal | Nat Genet | Volume | 36 |
| Issue | 10 | Pages | 1111-6 |
| PubMed ID | 15361870 | Mgi Jnum | J:93954 |
| Mgi Id | MGI:3510303 | Doi | 10.1038/ng1415 |
| Citation | Ding H, et al. (2004) A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling. Nat Genet 36(10):1111-6 |
| abstractText | PDGF-C is a member of the platelet-derived growth factor (PDGF) family, which signals through PDGF receptor (PDGFR) alphaalpha and alphabeta dimers. Here we show that Pdgfc(-/-) mice die in the perinatal period owing to feeding and respiratory difficulties associated with a complete cleft of the secondary palate. This phenotype was less severe than that of Pdgfra(-/-) embryos. Pdgfc(-/-) Pdgfa(-/-) embryos developed a cleft face, subepidermal blistering, deficiency of renal cortex mesenchyme, spina bifida and skeletal and vascular defects. Complete loss of function of both ligands, therefore, phenocopied the loss of PDGFR-alpha function, suggesting that both PDGF-A and PDGF-C signal through PDGFR-alpha to regulate the development of craniofacial structures, the neural tube and mesodermal organs. Our results also show that PDGF-C signaling is a new pathway in palatogenesis, different from, and independent of, those previously implicated. |
