| First Author | Zhou D | Year | 2008 |
| Journal | J Biol Chem | Volume | 283 |
| Issue | 1 | Pages | 541-53 |
| PubMed ID | 17971453 | Mgi Jnum | J:130294 |
| Mgi Id | MGI:3771443 | Doi | 10.1074/jbc.M703234200 |
| Citation | Zhou D, et al. (2008) Nuclear receptor coactivator PNRC2 regulates energy expenditure and adiposity. J Biol Chem 283(1):541-53 |
| abstractText | PNRC2 was identified in our laboratory as a general cofactor for nuclear receptors. To better characterize the physiological function of PNRC2, we used gene-targeting technology to generate PNRC2-null mice (PNRC2(-/-) mice). These PNRC2(-/-) mice are viable and fertile. PNRC2-null mice, especially male mice, are lean and are resistant to high fat diet-induced obesity but without the induction of insulin resistance. Male mice devoid of PNRC2 protein have a higher metabolic rate than wild-type mice. They consume more oxygen and produce more heat. Consistent with reduced adipose mass, the levels of leptin are lower in PNRC2(-/-) mice. This study provides evidence that PNRC2 plays one or more important roles in controlling the energy balance between energy storage and energy expenditure. PNRC2 may be a new target in the treatment of obesity and related metabolic diseases. |
