| First Author | Ilyin GP | Year | 2000 |
| Journal | Genomics | Volume | 67 |
| Issue | 1 | Pages | 40-7 |
| PubMed ID | 10945468 | Mgi Jnum | J:66302 |
| Mgi Id | MGI:1928246 | Doi | 10.1006/geno.2000.6211 |
| Citation | Ilyin GP, et al. (2000) cDNA cloning and expression analysis of new members of the mammalian F-box protein family. Genomics 67(1):40-7 |
| abstractText | F-box proteins are critical components of the SCF ubiquitin-protein ligase complex and are involved in substrate recognition and recruitment for ubiquitination and consequent degradation by the proteasome. We have isolated cDNAs encoding a further 10 mammalian F-box proteins. Five of them (FBL3 to FBL7) share structural similarities with Skp2 and contain C-terminal leucine-rich repeats. The other 5 proteins have different putative protein-protein interaction motifs. Specifically, FBS and FBWD4 proteins contain Sec7 and WD40-repeat domains, respectively. The C-terminal region of FBA shares similarity with bacterial protein ApaG while FBG2 shows homology with the F-box protein NFB42. The marked differences in F-box gene expression in human tissues suggest their distinct role in ubiquitin-dependent protein degradation. |
