| First Author | Setoguchi R | Year | 2008 |
| Journal | Science | Volume | 319 |
| Issue | 5864 | Pages | 822-5 |
| PubMed ID | 18258917 | Mgi Jnum | J:131081 |
| Mgi Id | MGI:3772948 | Doi | 10.1126/science.1151844 |
| Citation | Setoguchi R, et al. (2008) Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development. Science 319(5864):822-5 |
| abstractText | Mouse CD4+CD8+ double-positive (DP) thymocytes differentiate into CD4+ helper-lineage cells upon expression of the transcription factor Th-POK but commit to the CD8+ cytotoxic lineage in its absence. We report the redirected differentiation of class I-restricted thymocytes into CD4+CD8- helper-like T cells upon loss of Runx transcription factor complexes. A Runx-binding sequence within the Th-POK locus acts as a transcriptional silencer that is essential for Th-POK repression and for development of CD8+ T cells. Thus, Th-POK expression and genetic programming for T helper cell development are actively inhibited by Runx-dependent silencer activity, allowing for cytotoxic T cell differentiation. Identification of the transcription factors network in CD4 and CD8 lineage choice provides insight into how distinct T cell subsets are developed for regulating the adaptive immune system. |
