| First Author | Kukita T | Year | 2004 |
| Journal | J Exp Med | Volume | 200 |
| Issue | 7 | Pages | 941-6 |
| PubMed ID | 15452179 | Mgi Jnum | J:93945 |
| Mgi Id | MGI:3510294 | Doi | 10.1084/jem.20040518 |
| Citation | Kukita T, et al. (2004) RANKL-induced DC-STAMP is essential for osteoclastogenesis. J Exp Med 200(7):941-6 |
| abstractText | Osteoclasts are bone-resorbing, multinucleated giant cells that are essential for bone remodeling and are formed through cell fusion of mononuclear precursor cells. Although receptor activator of nuclear factor-kappaB ligand (RANKL) has been demonstrated to be an important osteoclastogenic cytokine, the cell surface molecules involved in osteoclastogenesis are mostly unknown. Here, we report that the seven-transmembrane receptor-like molecule, dendritic cell-specific transmembrane protein (DC-STAMP) is involved in osteoclastogenesis. Expression of DC-STAMP is rapidly induced in osteoclast precursor cells by RANKL and other osteoclastogenic stimulations. Targeted inhibition of DC-STAMP by small interfering RNAs and specific antibody markedly suppressed the formation of multinucleated osteoclast-like cells. Overexpression of DC-STAMP enhanced osteoclastogenesis in the presence of RANKL. Furthermore, DC-STAMP directly induced the expression of the osteoclast marker tartrate-resistant acid phosphatase. These data demonstrate for the first time that DC-STAMP has an essential role in osteoclastogenesis. |
