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Publication : Characterisation of the murine gene encoding the intracellular hyaluronan receptor IHABP (RHAMM).

First Author  Fieber C Year  1999
Journal  Gene Volume  226
Issue  1 Pages  41-50
PubMed ID  9889313 Mgi Jnum  J:52420
Mgi Id  MGI:1329267 Doi  10.1016/s0378-1119(98)00566-6
Citation  Fieber C, et al. (1999) Characterisation of the murine gene encoding the intracellular hyaluronan receptor IHABP (RHAMM). Gene 226(1):41-50
abstractText  We have recently shown that the published cDNA sequence encoding the murine cell surface receptor for hyaluronan-mediated motility (RHAMM) in fact represents a partial sequence of the cDNA encoding a new intracellular hyaluronic acid binding protein (IHABP). Here we publish the genomic organisation, including 700bp sequences of the promoter region, of the IHABP gene. The IHABP gene consists of 18 exons and spans more than 25kb. Part of the IHABP gene is identical with the published data on RHAMM. The IHABP gene apparently possesses one promoter region with one major transcriptional start point. IHABP is ubiquitously expressed at the mRNA and the protein level in all murine tissues, suggesting that the function of this intracellular hyaluronan binding protein is not restricted to migrating cells.
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