| First Author | Tobiume K | Year | 1997 |
| Journal | Biochem Biophys Res Commun | Volume | 239 |
| Issue | 3 | Pages | 905-10 |
| PubMed ID | 9367868 | Mgi Jnum | J:44039 |
| Mgi Id | MGI:1099290 | Doi | 10.1006/bbrc.1997.7580 |
| Citation | Tobiume K, et al. (1997) Molecular cloning and characterization of the mouse apoptosis signal-regulating kinase 1. Biochem Biophys Res Commun 239(3):905-10 |
| abstractText | The mouse cDNA for apoptosis signal-regulating kinase 1 (ASK)1 was isolated. The overall amino acid sequence identity between the mouse and the human ASK1 was 91.9%. A database search revealed that the kinase domain of ASK1 is evolutionally well-conserved over species among nematode, fly, mouse and human. Northern blot analysis identified a 6-kb transcript of ASK1 which is expressed in the various mouse adult tissues including heart, brain, lung, liver and kidney. Immunohistochemical analysis of mouse embryos (17 days post coitum) revealed a localized expression of ASK1 in developing skin, cartilage and bone, suggesting a possible role for ASK1 in tissue development during embryogenesis as well as cytokine-induced apoptosis. |
