| First Author | Nakamura TY | Year | 2001 |
| Journal | FEBS Lett | Volume | 499 |
| Issue | 3 | Pages | 205-9 |
| PubMed ID | 11423117 | Mgi Jnum | J:354378 |
| Mgi Id | MGI:7734772 | Doi | 10.1016/s0014-5793(01)02560-1 |
| Citation | Nakamura TY, et al. (2001) Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2. FEBS Lett 499(3):205-9 |
| abstractText | The Ca(2+)-binding protein, K(+) channel-interacting protein 1 (KChIP1), modulates Kv4 channels. We show here that KChIP1 affects Kv4.1 and Kv4.2 currents differently. KChIP1 slows Kv4.2 inactivation but accelerates the Kv4.1 inactivation time course. Kv4.2 activation is shifted in a hyperpolarizing direction, whereas a depolarizing shift occurs for Kv4.1. On the other hand, KChIP1 increases the current amplitudes and accelerates recovery from inactivation of both currents. An involvement of the Kv4 N-terminus in these differential effects is demonstrated using chimeras of Kv4.2 and Kv4.1. These results reveal a novel interaction of KChIP1 with these two Kv4 members. This represents a mechanism to further increase the functional diversity of K(+) channels. |
