| First Author | Inoue D | Year | 2012 |
| Journal | FEBS Lett | Volume | 586 |
| Issue | 10 | Pages | 1547-54 |
| PubMed ID | 22673524 | Mgi Jnum | J:185607 |
| Mgi Id | MGI:5429475 | Doi | 10.1016/j.febslet.2012.04.021 |
| Citation | Inoue D, et al. (2012) Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation. FEBS Lett 586(10):1547-54 |
| abstractText | Synapsins are neuronal phosphoproteins that coat synaptic vesicles and are believed to function in the regulation of neurotransmitter release. The signaling mechanism for short-chain free fatty acid (SCFA)-stimulated NE release was examined using primary-cultured mouse sympathetic cervical ganglion neurons. Pharmacological and knockdown experiments showed that activation of sympathetic neurons by SCFA propionate involves SCFA receptor GPR41 linking to G??-PLC?3-ERK1/2-synapsin 2 signaling. Further, synapsin 2b directly interacts with activated ERK1/2 and can be phosphorylated on serine when SCFA activates sympathetic neurons. |
