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Publication : Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila.

First Author  McGinnis W Year  1984
Journal  Cell Volume  38
Issue  3 Pages  675-80
PubMed ID  6091896 Mgi Jnum  J:7605
Mgi Id  MGI:56074 Doi  10.1016/0092-8674(84)90262-9
Citation  McGinnis W, et al. (1984) Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila. Cell 38(3):675-80
abstractText  Some of the homeotic genes of Drosophila, involved in the control of segmental development, form a diverged multigene family. A conserved DNA sequence common to these genes has been used to isolate a clone (Mo-10) from the mouse genome which contains a sequence coding for a protein domain that is homologous to the domain conserved in the Drosophila homeotic genes. By structural analogy, this sequence may be involved in the control of metameric pattern formation in the mouse. Mo-10 has been mapped to the proximal portion of mouse chromosome 6, and its position in relationship to genes known to influence mouse morphogenesis is discussed.
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