| First Author | Deutsch U | Year | 1988 |
| Journal | Cell | Volume | 53 |
| Issue | 4 | Pages | 617-25 |
| PubMed ID | 2453291 | Mgi Jnum | J:9186 |
| Mgi Id | MGI:57649 | Doi | 10.1016/0092-8674(88)90577-6 |
| Citation | Deutsch U, et al. (1988) Pax 1, a member of a paired box homologous murine gene family, is expressed in segmented structures during development. Cell 53(4):617-25 |
| abstractText | The mouse genome contains at least three copies of sequences homologous to the paired box, a conserved domain in several Drosophila segmentation genes of the pair-rule and segment polarity classes. Overlapping phages were isolated from two different genomic libraries using the Drosophila gooseberry distal paired box as a probe. The hybridizing sequences are highly homologous to the conserved Drosophila paired box sequences. A single 3.1 kb Pax 1 (paired box gene) transcript was detected during embryonic development, whereas no transcripts were detected in adult tissues. Detailed in situ hybridization analyses with frozen embryonic sections demonstrated Pax 1 transcripts in the perichordal zone of the developing vertebral column. The expression pattern suggests a role for this gene in the formation of segmented structures of the mouse embryo. |
