| First Author | Westaway D | Year | 1987 |
| Journal | Cell | Volume | 51 |
| Issue | 4 | Pages | 651-62 |
| PubMed ID | 2890436 | Mgi Jnum | J:8918 |
| Mgi Id | MGI:57383 | Doi | 10.1016/0092-8674(87)90134-6 |
| Citation | Westaway D, et al. (1987) Distinct prion proteins in short and long scrapie incubation period mice. Cell 51(4):651-62 |
| abstractText | The Prn-i gene, controlling scrapie incubation period, is linked to or congruent with the murine prion protein (PrP) gene, Prn-p. In prototypic mouse strains with long (l/Ln) and short (NZW) incubation periods, Prn-p transcription is initiated at similar multiple sites. The predicted NZW and l/Ln PrP proteins differ at codons 108 and 189. Codon 189, highly conserved in mammals, lies within a polymorphic BstEll site that is retained in 17 mouse strains known to have short or intermediate incubation times, but is absent in l/Ln and two other inbred mice with long incubation times. Codon 108 in mice with short or intermediate incubation times encodes Leu; in mice with long incubation times it encodes Phe. The correlation of PrP sequence with length of scrapie incubation period suggests, but does not formally prove, congruency between Prn-p and Prn-i. |
