| First Author | Kim SF | Year | 2005 |
| Journal | Science | Volume | 310 |
| Issue | 5756 | Pages | 1966-70 |
| PubMed ID | 16373578 | Mgi Jnum | J:168203 |
| Mgi Id | MGI:4887336 | Doi | 10.1126/science.1119407 |
| Citation | Kim SF, et al. (2005) Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science 310(5756):1966-70 |
| abstractText | Cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. Here we show that iNOS specifically binds to COX-2 and S-nitrosylates it, enhancing COX-2 catalytic activity. Selectively disrupting iNOS-COX-2 binding prevented NO-mediated activation of COX-2. This synergistic molecular interaction between two inflammatory systems may inform the development of anti-inflammatory drugs. |
