| First Author | Blum M | Year | 1992 |
| Journal | Cell | Volume | 69 |
| Issue | 7 | Pages | 1097-106 |
| PubMed ID | 1352187 | Mgi Jnum | J:1337 |
| Mgi Id | MGI:49864 | Doi | 10.1016/0092-8674(92)90632-m |
| Citation | Blum M, et al. (1992) Gastrulation in the mouse: the role of the homeobox gene goosecoid. Cell 69(7):1097-106 |
| abstractText | Mouse goosecoid is a homeobox gene expressed briefly during early gastrulation. Its mRNA accumulates as a patch on the side of the epiblast at the site where the primitive streak is first formed. goosecoid-expressing cells are then found at the anterior end of the developing primitive streak, and finally in the anteriormost mesoderm at the tip of the early mouse gastrula, a region that gives rise to the head process. Treatment of early mouse embryos with activin results in goosecoid mRNA accumulation in the entire epiblast, suggesting that a localized signal induces goosecoid expression during development. Transplantation experiments indicate that the tip of the murine early gastrula is the equivalent of the organizer of the amphibian gastrula. |
