| First Author | Bosse A | Year | 1997 |
| Journal | Mech Dev | Volume | 69 |
| Issue | 1-2 | Pages | 169-81 |
| PubMed ID | 9486539 | Mgi Jnum | J:45683 |
| Mgi Id | MGI:1195838 | Doi | 10.1016/s0925-4773(97)00165-2 |
| Citation | Bosse A, et al. (1997) Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system. Mech Dev 69(1-2):169-81 |
| abstractText | In Drosophila the decision processes between the neural and epidermal fate for equipotent ectodermal cells depend on the activity of proneural genes. Members of the Drosophila Iroquois-Complex (Iro-C) positively regulate the activity of certain proneural AS-C genes during the formation of external sensory organs. We have identified and characterized three mouse Iroquois-related genes: Irx1, -2 and -3, which have a homeodomain very similar to that of the Drosophila Iro-C genes. The sequence similarity implies that these three genes represent a separate homeobox family. All three genes are expressed with distinct spatio/temporal patterns during early mouse embryogenesis. These patterns implicate them in a number of embryonic developmental processes: the A/P and D/V patterning of specific regions of the central nervous system (CNS), and regionalization of the otic vesicle, branchial epithelium and limbs. |
