| First Author | Kawai T | Year | 2002 |
| Journal | Biosci Biotechnol Biochem | Volume | 66 |
| Issue | 10 | Pages | 2134-45 |
| PubMed ID | 12450124 | Mgi Jnum | J:102673 |
| Mgi Id | MGI:3607897 | Doi | 10.1271/bbb.66.2134 |
| Citation | Kawai T, et al. (2002) Molecular cloning of mouse collectin liver 1. Biosci Biotechnol Biochem 66(10):2134-45 |
| abstractText | Collectins are members of the superfamily of vertebrate C-type lectins that contain a collagen-like region, and are involved in first-line host defense. We earlier cloned and characterized a new kind of collectin, collectin liver 1 (CL-L1). In this study, we isolated the mouse homologue of CL-L1 encoding 277 amino acid residues; its deduced protein sequence was 88% identical with human CL-L1. Mouse CL-L1 mRNA was expressed mainly in the liver and stomach, but was found also in muscles, testes, intestines, and embryos. In mouse embryos, the level of CL-L1 mRNA gradually increased with embryonic age. In 16-day-old mouse embryos, CL-L1 mRNA was expressed in the liver, amnion, and visceral yolk sac. The mouse CL-L1 gene, Cll1 was found on chromosome 15 in a region syntenic with human chromosome 8q. CL-L1 was a highly conserved protein in mammals, birds, and fish. |
