| First Author | Givol D | Year | 1981 |
| Journal | Nature | Volume | 292 |
| Issue | 5822 | Pages | 426-30 |
| PubMed ID | 6789211 | Mgi Jnum | J:6547 |
| Mgi Id | MGI:55023 | Doi | 10.1038/292426a0 |
| Citation | Givol D, et al. (1981) Diversity of germ-line immunoglobulin VH genes. Nature 292(5822):426-30 |
| abstractText | The sequences of four embryonic mouse immunoglobulin VH genes have been compared. All genes end at codon 98 and code for a hydrophobic signal peptide of 19 residues interrupted at codon -4 by an intron of 83 base pairs. Substitutions occur in all gene segments but at a significantly higher frequency in the hypervariable regions. The data suggest an evolutionary basis for the diversity of immunoglobulin genes. Divergence resulted also in a termination codon in two of the genes, suggesting that part of the V gene repertoire cannot be expressed unless some correction mechanism is available. |
