| First Author | Morozov A | Year | 1995 |
| Journal | FEBS Lett | Volume | 371 |
| Issue | 3 | Pages | 214-8 |
| PubMed ID | 7556594 | Mgi Jnum | J:36296 |
| Mgi Id | MGI:83761 | Doi | 10.1016/0014-5793(95)00884-c |
| Citation | Morozov A, et al. (1995) HPV16 E7 oncoprotein induces expression of a 110 kDa heat shock protein. FEBS Lett 371(3):214-8 |
| abstractText | Heat shock protein genes are induced by various kinds of stress. Besides stress, the heat shock family gene hsp70 has been shown to be induced by growth-stimulating agents such as the DNA virus oncoproteins and serum. Here, we report cloning of a novel cDNA that encodes a 100 kDa heat shock protein-related polypeptide as a human papillomavirus oncoprotein E7-inducible gene. E7 induces expression of this heat shock protein at the level of RNA synthesis. Moreover, the induction of this heat shock protein-mRNA was dependent on the conserved region 2 of the E7 protein, which is essential for binding to the proteins of the retinoblastoma family. |
