| First Author | Smith KG | Year | 1998 |
| Journal | J Exp Med | Volume | 187 |
| Issue | 5 | Pages | 807-11 |
| PubMed ID | 9480991 | Mgi Jnum | J:111097 |
| Mgi Id | MGI:3653013 | Doi | 10.1084/jem.187.5.807 |
| Citation | Smith KG, et al. (1998) Inhibition of the B cell by CD22: a requirement for Lyn. J Exp Med 187(5):807-11 |
| abstractText | Mice in which the Lyn, Cd22, or Shp-1 gene has been disrupted have hyperactive B cells and autoantibodies. We find that in the absence of Lyn, the ability of CD22 to become tyrosine phosphorylated after ligation of mIg, to recruit SHP-1, and to suppress mIg-induced elevation of intracellular [Ca2+] is lost. Therefore, Lyn is required for the SHP-1-mediated B cell suppressive function of CD22, accounting for similarities in the phenotypes of these mice. |
