| First Author | Singh TD | Year | 2010 |
| Journal | FEBS Lett | Volume | 584 |
| Issue | 18 | Pages | 3936-42 |
| PubMed ID | 20828568 | Mgi Jnum | J:164422 |
| Mgi Id | MGI:4833881 | Doi | 10.1016/j.febslet.2010.08.050 |
| Citation | Singh TD, et al. (2010) MEGF10 functions as a receptor for the uptake of amyloid-beta. FEBS Lett 584(18):3936-42 |
| abstractText | MEGF10 is predominantly expressed in the brain and known to function as a phagocytic receptor. Here, we provide evidence that MEGF10 is involved in the uptake of amyloid-beta peptide (Abeta42) in the brain. Overexpression of MEGF10 dramatically increased Abeta42 uptake in Hela cells. Knockdown of endogenous MEGF10 expression significantly decreased Abeta42 uptake in N2A neuroblastoma cells. MEGF10-mediated Abeta uptake is mostly dependent on lipid raft endocytosis pathway. Furthermore, site-directed mutagenesis revealed that the conserved cytoplasmic NPxY and YxxO motifs are crucial for MEGF10-mediated uptake of Abeta42 peptide. Thus, the identification of the MEGF10 as a functional receptor that mediates the uptake of amyloid-beta peptide will help elucidate the molecular mechanisms of amlyoid-beta clearance in Alzheimer's disease. |
