| First Author | Janssen E | Year | 2003 |
| Journal | Nat Immunol | Volume | 4 |
| Issue | 2 | Pages | 117-23 |
| PubMed ID | 12514734 | Mgi Jnum | J:121605 |
| Mgi Id | MGI:3710721 | Doi | 10.1038/ni882 |
| Citation | Janssen E, et al. (2003) LAB: a new membrane-associated adaptor molecule in B cell activation. Nat Immunol 4(2):117-23 |
| abstractText | The adaptor molecule, linker for activation of T cells (LAT), is essential in T cell activation and development; a similar molecule in B cells has not yet been identified. Here, we report the identification of a new adaptor protein, linker for activation of B cells (LAB). Like LAT, LAB was localized to lipid rafts. Upon activation via the B cell receptor (BCR), LAB was phosphorylated and interacted with the adaptor protein Grb2. Decreased LAB expression led to a reduction in BCR-mediated calcium flux and Erk activation. LAB rescued thymocyte development but not normal T cell activation in LAT(-/-) mice. Our data suggest that LAB links BCR engagement to downstream signaling pathways. |
