| First Author | Davis JA | Year | 1989 |
| Journal | Mol Endocrinol | Volume | 3 |
| Issue | 4 | Pages | 674-80 |
| PubMed ID | 2725531 | Mgi Jnum | J:32405 |
| Mgi Id | MGI:79901 | Doi | 10.1210/mend-3-4-674 |
| Citation | Davis JA, et al. (1989) Expression of multiple forms of the prolactin receptor in mouse liver. Mol Endocrinol 3(4):674-80 |
| abstractText | We have characterized the PRL receptor (PRL-R) present in mouse liver by purification, cross-linking, and immunological analysis of the protein, and by the isolation of PRL-R cDNA clones. Analysis of the cDNA clones indicates that the liver receptor is actually a family of proteins. Two of these proteins are predicted to be synthesized as precursors of 303 and 292 amino acids, with common signal sequences, extracellular domains, and transmembrane domains; a portion of their cytoplasmic domains are also identical, but these proteins differ markedly in the terminal region of this domain. A third PRL-R protein is predicted to be a truncated form and may be secreted. These multiple PRL-R mRNAs appear to be encoded by at least two genes, with the sequence variation for the two full-length proteins likely due to alternative RNA splicing. These results suggest that the varied actions of PRL may involve multiple receptors that are part of distinct signal transduction pathways. |
