| First Author | Schughart K | Year | 1988 |
| Journal | Proc Natl Acad Sci U S A | Volume | 85 |
| Issue | 15 | Pages | 5582-6 |
| PubMed ID | 2899893 | Mgi Jnum | J:9272 |
| Mgi Id | MGI:57734 | Doi | 10.1073/pnas.85.15.5582 |
| Citation | Schughart K, et al. (1988) Structure and expression of Hox-2.2, a murine homeobox-containing gene. Proc Natl Acad Sci U S A 85(15):5582-6 |
| abstractText | The Hox-2.2 gene is one of a cluster of homeobox-containing genes on mouse chromosome 11. A cDNA clone containing the Hox-2.2 homeobox has been isolated from an adult spinal cord library. Our analysis of the Hox-2.2 cDNA and genomic clones indicates that there are at least two oxons and one intron. The largest open reading frame includes the homeobox and codes for a 224 amino acid protein of molecular weight 25,312. Comparisons of the predicted Hox-2.2 protein with other homeodomain-containing proteins revealed four regions of sequence similiarity: an N-terminal octapeptide, a hexapeptide upstream of the homeodomain, the homeodomain, and a glutamic acid-rich region at the C terminus. Possible functions of these regions are discussed. The Hox-2.2 gene is expressed in 13.5-day embryos in the developing hindbrain and spinal cord. The expression patterns of Hox-2.2 and Hox-2.1 in 13.5-day embryos are compared. |
