| First Author | Yang YS | Year | 1993 |
| Journal | Mol Cell Biol | Volume | 13 |
| Issue | 9 | Pages | 5593-603 |
| PubMed ID | 8355702 | Mgi Jnum | J:24184 |
| Mgi Id | MGI:71938 | Doi | 10.1128/mcb.13.9.5593 |
| Citation | Yang YS, et al. (1993) NonO, a non-POU-domain-containing, octamer-binding protein, is the mammalian homolog of Drosophila nonAdiss. Mol Cell Biol 13(9):5593-603 |
| abstractText | We have cloned the ubiquitous form of an octamer-binding, 60-kDa protein (NonO) that appears to be the mammalian equivalent of the Drosophila visual and courtship song behavior protein, no-on-transient A/dissonance (nonAdiss). A region unprecedently rich in aromatic amino acids containing two ribonuclear protein binding motifs is highly conserved between the two proteins. A ubiquitous form of NonO is present in all adult tissues, whereas lymphocytes and retina express unique forms of NonO mRNA. The ubiquitous form contains a potential helix-turn-helix motif followed by a highly charged region but differs from prototypic octamer-binding factors by lacking the POU DNA-binding domain. In addition to its conventional octamer duplex-binding, NonO binds single-stranded DNA and RNA at a site independent of the duplex site. |
