| First Author | Zhou Y | Year | 2000 |
| Journal | Biochem Biophys Res Commun | Volume | 268 |
| Issue | 3 | Pages | 921-7 |
| PubMed ID | 10679306 | Mgi Jnum | J:333123 |
| Mgi Id | MGI:7434529 | Doi | 10.1006/bbrc.2000.2231 |
| Citation | Zhou Y, et al. (2000) Mouse peroxiredoxin V is a thioredoxin peroxidase that inhibits p53-induced apoptosis. Biochem Biophys Res Commun 268(3):921-7 |
| abstractText | We have identified human and mouse peroxiredoxin V (Prx-V) by virtue of the sequence homologies to yeast peroxisomal antioxidant enzyme PMP20. Prx-V represents the fifth of the six currently known subfamilies of mammalian peroxiredoxins. It is a novel organellar enzyme that has orthologs in bacteria. Biochemically, Prx-V is a thioredoxin peroxidase. One important aspect of p53 function in mammalian cells involves induction of apoptosis likely mediated by redox. We show that overexpression of Prx-V prevented the p53-dependent generation of reactive oxygen species. Likewise, Prx-V inhibited p53-induced apoptosis. Thus, Prx-V is critically involved in intracellular redox signaling. |
