| First Author | Ogura Y | Year | 2016 |
| Journal | Nat Chem Biol | Volume | 12 |
| Issue | 9 | Pages | 669-71 |
| PubMed ID | 27399000 | Mgi Jnum | J:287058 |
| Mgi Id | MGI:6414734 | Doi | 10.1038/nchembio.2127 |
| Citation | Ogura Y, et al. (2016) A calcium-dependent acyltransferase that produces N-acyl phosphatidylethanolamines. Nat Chem Biol 12(9):669-71 |
| abstractText | More than 30 years ago, a calcium-dependent enzyme activity was described that generates N-acyl phosphatidylethanolamines (NAPEs), which are precursors for N-acyl ethanolamine (NAE) lipid transmitters, including the endocannabinoid anandamide. The identity of this calcium-dependent N-acyltransferase (Ca-NAT) has remained mysterious. Here, we use activity-based protein profiling to identify the poorly characterized serine hydrolase PLA2G4E as a mouse brain Ca-NAT and show that this enzyme generates NAPEs and NAEs in mammalian cells. |
