| First Author | Tischfield JA | Year | 1996 |
| Journal | Genomics | Volume | 32 |
| Issue | 3 | Pages | 328-33 |
| PubMed ID | 8838795 | Mgi Jnum | J:31958 |
| Mgi Id | MGI:79462 | Doi | 10.1006/geno.1996.0126 |
| Citation | Tischfield JA, et al. (1996) Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human. Genomics 32(3):328-33 |
| abstractText | The Group IIA phospholipase gene (PLA2G2A) protein coding regions exhibit significant homology with recently described Group IIC (PLA2G2C) and Group V (PLA2GV) genes, All three genes are present in many mammalian species and are expressed in a tissue-specific pattern. Here, we demonstrate in human that they are tightly linked and map to chromosome 1p34-p36.1. We also show that the homologous mouse loci are tightly linked (no observed recombination) on the distal part of chromosome 4, a region exhibiting synteny with human 1p34-p36, Unlike its rodent counterpart, human PLA2G2C appears to be a nonfunctional pseudogene. (C) 1996 Academic Press, Inc. |
