| First Author | Peitsch MC | Year | 1995 |
| Journal | Biochem Biophys Res Commun | Volume | 207 |
| Issue | 1 | Pages | 62-8 |
| PubMed ID | 7857306 | Mgi Jnum | J:22846 |
| Mgi Id | MGI:70734 | Doi | 10.1006/bbrc.1995.1153 |
| Citation | Peitsch MC, et al. (1995) Genomic organisation and expression of mouse deoxyribonuclease I. Biochem Biophys Res Commun 207(1):62-8 |
| abstractText | Deoxyribonuclease I (DNase I) has recently been implicated in cell death by apoptosis, a process which is frequently accompanied by chromatin DNA degradation. Despite extensive studies on DNase I, its genomic organisation remained unknown. Here we report for the first time on the intron-exon structure of the DNase I gene. The coding region of mouse DNase I is composed of eight introns and eight exons, spanning 2315 base pairs. The deduced protein sequence is 91.5% identical to its rat counterpart, but does not carry the two mutations (Glu13 to D and V67 to I) responsible for the decrease in actin-binding of rat DNase I. The enzymatic activity of mouse DNase I is found in striated muscle, kidney, intestine, liver, lymphnodes, but not in the heart, spleen or pancreas. |
