| First Author | Ko LJ | Year | 1991 |
| Journal | Mol Cell Biol | Volume | 11 |
| Issue | 5 | Pages | 2778-84 |
| PubMed ID | 2017177 | Mgi Jnum | J:20800 |
| Mgi Id | MGI:68870 | Doi | 10.1128/mcb.11.5.2778 |
| Citation | Ko LJ, et al. (1991) Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer. Mol Cell Biol 11(5):2778-84 |
| abstractText | A family of transcriptional activators has recently been identified in chickens; these transcriptional activators recognize a common consensus motif (WGATAR) through a conserved C4 zinc finger DNA-binding domain. One of the members of this multigene family, cGATA-3, is most abundantly expressed in the T-lymphocyte cell lineage. Analysis of human and murine GATA-3 factors shows a striking degree of amino acid sequence identity and similar patterns of tissue specificity of expression in these three organisms. The murine and human factors are abundantly expressed in a variety of human and murine T-cell lines and can activate transcription through a tissue-specific GATA-binding site identified within the human T-cell receptor delta gene enhancer. We infer that the murine and human GATA-3 proteins play a central and highly conserved role in vertebrate T-cell-specific transcriptional regulation. |
