| First Author | Ho AM | Year | 2000 |
| Journal | Science | Volume | 289 |
| Issue | 5477 | Pages | 265-70 |
| PubMed ID | 10894769 | Mgi Jnum | J:63420 |
| Mgi Id | MGI:1860991 | Doi | 10.1126/science.289.5477.265 |
| Citation | Ho AM, et al. (2000) Role of the mouse ank gene in control of tissue calcification and arthritis [see comments]. Science 289(5477):265-70 |
| abstractText | Mutation at the mouse progressive ankylosis (ank) locus causes a generalized, progressive form of arthritis accompanied by mineral deposition, formation of bony outgrowths, and joint destruction. Here, we show that the ank locus encodes a multipass transmembrane protein (ANK) that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. A highly conserved gene is present in humans and other vertebrates. These results identify ANK-mediated control of pyrophosphate levels as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals. |
