| First Author | Hoshino A | Year | 2007 |
| Journal | FEBS Lett | Volume | 581 |
| Issue | 5 | Pages | 975-80 |
| PubMed ID | 17300783 | Mgi Jnum | J:119185 |
| Mgi Id | MGI:3701414 | Doi | 10.1016/j.febslet.2007.01.083 |
| Citation | Hoshino A, et al. (2007) Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon. FEBS Lett 581(5):975-80 |
| abstractText | Cytokines control cell differentiation, proliferation, and function by regulating gene expression program. Physiological roles and induction mechanisms of cytokine-inducible genes are not fully understood. Here, we identified a novel immediate-early cytokine-responsive gene, cyclon (cytokine-induced protein with coiled-coil domain), which is induced in a hematopoietic cell line by interleukin 3 (IL-3). cyclon gene encodes a phosphorylated nuclear protein consisting of repetitive sequences in the amino-terminus and a coiled-coil domain in the carboxyl-terminus. A novel transient reporter assay revealed that mouse cyclon promoter contains redundant elements for IL-3-induced gene expression. |
